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From: ASundstrom on 23 Jun 2010 12:30 I found that when I tried to log into the Central Administration site on the SharePoint application server that I received multiple user prompts, followed by a failed authentication with 401 1 3221225581 0 errors in the IIS logs. We have NTLM configured for SharePoint, SSL forced and use an ALIAS for the sites. I found the following link, which helped me come to the conclusion that it had something to do with NTLM. I had run into a similar problem trying to use SharePoint on an NLB and found the following link and information which fixed my problem, so I thought I would share. A. Disable Loop Back Checking for the ALIAS 1. You may experience this error in the IIS logs “401 1 3221225581 0” 2. http://support.microsoft.com/kb/896861 3. Click Start, click Run, type regedit, and then click OK. 4. In Registry Editor, locate and then click the following registry key: 5. HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Lsa 6. Right-click MSV1_0, point to New, and then click MultiString Value. 7. Type BackConnectionHostNames, then press ENTER and input the different FQDN's that you will be using. 7.1. IE – admin.sharepoint.dot.nc.net 8. Quit Registry Editor 9. Try navigating the site and see if it tries to re-authenticate.
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