From: Fuaada on
Hello, after some trials adjusting the TolX and TolFun (as suggested by James), i managed to find the parameter values.It is working.....thanks everybody!

Fuaada

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From: fuaada mohd siam on
Hi all,

Corresponds to my previous question, even though i got the answer, i still unclear about the process..

I have n number of linear odes which contain 6 parameters. Here I have linear ODE system, N'=AN in matrix form. which A is non-diagonal matrix since i have coupled equations. The solution of the system is N(t)=Noexp(At). My case, No is a random initial condition and A containing parameter gamma,alpha1,alpha2,p,Vmax,Km. p is the probability.

I really need some advise for which parameter estimation solver should i refer to...
Are all the solver must require a starting parameter value. Is there any solver without asking the starting value?....or i should use Maximum Likelihood Estimation or Markov Chain Monte Carlo approach? I really have no idea about those approach...i have very little knowledge of statistical tool.....please help....

Fuaada